The Science of Lipogems

Lipogems® Canine takes the science of Lipogems® International SPA and has shown that its application in numerous trials in human medicine has had huge success in the treatment of a range of common conditions and diseases in dogs. There is a huge amount of science and research behind what the Lipogems® Canine team are able to apply to your best friend. Here are just some of the more in depth details about how the science works. To see the outcomes of some of the cases that have been treated in the click here. To read the full scientific story of Lipogems® click here to visit the Lipogems® International SPA website. If you are a vet and would like to read our comprehensive presentation on the science behind Lipogems® Canine complete with case studies and links for further reading click here.

1. Pericyte subset transitional between pericytes and supra-adventitial adiose stromal cells and/or a set of endothelial (progenitor) cells

Damage Response Mechanism

Lipogems® Preserves viable elements with Pericyte identity which, after an injury detach from the capillaries and gradually convert into activated Mesenchymal Stromal Cells (MSCs).

The Lipogems® process acts as a replica of damage to cells in a trauma situation encouraging cells to behave as if an injury has occurred.

PERICYTE ~ MSC ~ ACTIVATED MSC

The Science Behind Lipogems®

Cell Characterisation

Lipogems® Contains more Mesenchymal Stromal Cells (MSCs), Pericytes and Transitional Pericytes than Lipoaspirate. Due to the intact vascular stromal niche Lipogems® acts as a natural scaffold preserving activated MSCs.

We can find Pericytes in Adipose Tissue

Pericytes exist in adipose tissue niche wrapped around capillaries within adipocyte clusters; Pericytes react to signals from injury or damage

Lipogems is Not a Stem Cell Therapy ~ Mesenchymal Stromal Cells vs. Mesenchymal Stem Cells

Click on the links below for the following papers regarding MSC criteria and features:

Mammalian MSC from selected species: Features and applications.
Uder C1, Brückner S1, Winkler S1, Tautenhahn HM1, Christ B.

Click here to read the abstract and download the paper.

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.
Dominici M1, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E.

Click here to read the abstract and download the paper.

Lipogems® VS Adipose Tissue

Lipogems® samples show a maintained vascular stroma consisting of slit-like capillaries containing vascular channels with evident lumina; on the contrary, conventionally treated fat tissue shows compressed and distorted microchannels.

Lipogems® Canine is a new innovative application of regenerative technology available from referral veterinary surgeons for a range of conditions including orthopaedic and soft tissue injuries and diseases including osteoarthritis. Veterinary treatment for you dog can be considered by asking your first referral veterinary surgeon to refer your case to one of our centres. To find a referral centre click here. #lipogemscanine

LipoGEMS CANINE

Saving Your Best Friend

Bianchi, Francesca, et al. “A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates.” Cell transplantation 22.11 (2013): 2063-2077.

Professor Arnold Caplan

Is “The father of the MSC”, in this clip he explains how this new branch of science works.
"You are ALIVE because you continuously renew (rejuvenate) various tissues/organs. Within the body, cells of the skin, gut, and blood, among others come to maturation, function for a time and then expire to be replaced by a continuous stream of cells which renew the tissue."
Professor Arnold I. Caplan, Ph.D (2008), Skeletal Research Center, Case Western Reserve University and NJ Symp Biomat & Regen Med